Effect of the Nature of the Particles Released from Bone Level Dental Implants: Physicochemical and Biological Characterization

The placement of bone–level dental implants can lead to the detachment particles in surrounding tissues due friction with cortical bone. In this study, 60 were placed same design: 30 made commercially pure grade 4 titanium and Ti6Al4V alloy. These cow ribs following company’s protocols. Particles detached from isolated their size specific surface area characterized. irregular morphology was observed by scanning electron microscopy. Ion release medium determined at different immersion times physiological medium. Cytocompatibility studies performed fibroblastic osteoblastic cells. Gene expression cytokine analysed determine action inflammatory Particle sizes around 15 ?M obtained both cases. alloy showed significant levels vanadium ion cytocompatibility these is lower than that titanium. presents higher inflammation markers (TNF? Il–1?) compared only Therefore, there a trend greater toxicity pro-inflammatory response.